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A welcome message from the Chief

Dr. Sudhir Gupta, chief of the Division of Basic and Clinical Immunology
Kerrin Piché Serna / University Communications
Dr. Sudhir Gupta, chief of the Division of Basic and Clinical Immunology at UC Irvine's School of Medicine

The Division of Basic and Clinical Immunology is dedicated to providing compassionate, state-of-the-art diagnostic and therapeutic care to children and adults with immunological and allergic diseases. Our faculty members are nationally and internationally recognized for fostering basic, clinical and translational research, and they are committed to training physicians and scientists for academic careers in immunology and allergy.

We are one of only 50 Jeffrey Modell Centers for Primary Immunodeficiency diseases worldwide. These centers are dedicated to providing state-of-the-art diagnostic and therapeutic care to children and adults with primary immunodeficiencies.

Patients with primary immunodeficiency diseases are central to the study of the immune system and diseases associated with it. We follow approximately 250 children and adults with primary immunodeficiencies in our physician offices.

The Division of Basic and Clinical Immunology has one of the most competitive ACGME-accredited post-doctoral training programs in allergy and immunology.

Fellows are trained in primary immunodeficiency diseases, HIV/AIDS, autoimmune diseases, and allergic diseases. Fellows and residents have ample opportunities to participate in basic, translational, or clinical research. Our training program provides extensive didactic core lectures, seminars, and a journal club in basic immunology, clinical immunology, and allergy in the United States. In addition, our division organizes the annual international symposium on primary immunodeficiency diseases, and biennially an international conference on a variety of progressive subjects in immunology. 

The Division of Basic and Clinical Immunology has extensive research programs, which provide medical students and residents in pediatrics and general internal medicine with the unique opportunities to address important clinical and basic research questions in the laboratories via translational and basic research. These include basic research in somatic hypermutation and class-switch recombination, which has been instrumental in defining the genetic basis of a number of primary immunodeficiency diseases; apoptosis or programmed cell death, and dendritic cell biology. Our division also is heavily involved in translational research in human aging and primary immunodeficiency diseases.

It is our mission to train the best scientists and clinicians, to recruit and retain the most outstanding faculty and to provide best care for our patients.